Rev-erb and Rev-erb coordinately protect the circadian clock and normal metabolic function
نویسندگان
چکیده
منابع مشابه
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-a and REV-ERB-b have been proposed to form an accessory feedback loop that contributes to clock function, their precise roles and importance remain unresolved. To establish their regulatory potential, w...
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Duez H, Staels B. Rev-erb: an integrator of circadian rhythms and metabolism. J Appl Physiol 107: 1972–1980, 2009. First published August 20, 2009; doi:10.1152/japplphysiol.00570.2009.—The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are gen...
متن کاملDirect Regulation of CLOCK Expression by REV-ERB
Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY). The CLOCK and BMAL1 proteins are members of the bHLH class of transcription factors and form a heterodimer that regulates the expression of the PER and CRY genes. The nuclear receptor REV-ERBα ...
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The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbalpha expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to expression of adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for REV-ERB, and binding of heme is required for the receptor's activity. We therefore hypothesiz...
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Nuclear hormone receptors (NRs) function as ligand dependent DNA binding proteins that translate physiological/nutritional signals into gene regulation. Dysfunctional NR signaling leads to many disorders in reproduction, inflammation, and metabolism. The opportunity to identify novel regulatory pathways in the context of human health and disease drives the challenge to unravel the biological fu...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2012
ISSN: 0890-9369
DOI: 10.1101/gad.186858.112